Indolmycin

Indolmycin is a highly selective antibiotic which acts as a tryptophan anti-metabolite. Recent research has shown that Indolmycin is active against Mycobacteria and H. pylori, and can stimulate transcription in Escherichia coli.

Indolmycin is a member of the class of 1,3-oxazoles.  It has a role as an antimicrobial, an antibacterial, a bacterial metabolite and an EC 6.1.1.2 (tryptophan-tRNA ligase) inhibitor.

Indolmycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Molecular Formula

C14H15N3O2

References

Bogosian G et al (1983)  Indolmycin-mediated inhibition and stimulation of transcription at the trp promoter of Escherichia coli.  J. Bacteriol. 153:1120 Hasuoka A (2001)  Development of a stereoselective practical synthetic route to Indolmycin, a candidate anti-H. pylori agent. Chem Pharm. Bull. 49:1604 Kitabatake M et al (2002)  Indolmycin resistance of Streptomyces coelicolor A3(2) by induced expression of one of its two tryptophanyl-tRNA synthetases. J Biol. Chem. 277:23882