Indolmycin is a natural product and highly selective antibiotic which acts as a tryptophan anti-metabolite. Recent research has shown that it is active against Mycobacteria and Helicobacter pylori, and can stimulate transcription in Escherichia coli.
Indolmycin is a member of the class of 1,3-oxazoles. It has a role as an antibacterial, bacterial metabolite and an EC 6.1.1.2 (tryptophan-tRNA ligase) inhibitor.
Indolmycin is soluble in ethanol, methanol, DMF or DMSO.
| Molecular Formula | C14H15N3O2 |
| Mechanism of Action | Indolmycin selectively inhibits bacterial tryptophanyl-tRNA synthetase (TrpRS). |
| Microbiology | Indolmycin displayed potent activity against methicillin-sensitive and methicillin-resistant Staphylococcus aureus, as well as Mycobacterium tuberculosis. Authors tested both natural and synthetic Indolmycin and found it had negligible cytotoxicity toward L929 cells at antimycobacterial concentrations, supporting its use as a potential anti-tuberculosis candidate. |
| References |
Bogosian G et al (1983) Indolmycin-mediated inhibition and stimulation of transcription at the trp promoter of Escherichia coli. J. Bacteriol. 153:1120 Kitabatake M et al (2002) Indolmycin resistance of Streptomyces coelicolor A3(2) by induced expression of one of its two tryptophanyl-tRNA synthetases. J Biol. Chem. 277:23882 Yang et al (2022) Investigate natural product Indolmycin and the synthetically improved analogue toward antimycobacterial agents. ACS Chem. Biol. 17(1):39–53 |