Isavoconazole is an Azol antifungal of the triazole class with broad-spectrum antifungal activity. It was discovered in Kamakura, Japan (Roche). It exhibits antifungal activity against bacteria causing invasive aspergillosis (Aspergillus flavus, Aspergillus fumigatus, and Aspergillus niger). Isavuconazole is also effective against Mucorales such as Rhizopus oryzae, and Mucormycetes.
|Mechanism of Action||Isavuconazole disrupts the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. It inhibits the cytochrome P450-dependent enzyme lanosterol 14-alpha-demethylase, that mediates the conversion of lanosterol to ergosterol. Depletion of ergosterol within the fungal cell membrane leads to decreased structural integrity and function of the cell membrane.|
|References||Miceli MH, Kauffman CA (2015) Isavuconazole: A new broad-spectrum triazole antifungal agent. Clin. Infect. Dis. 61 (10):1558–1565 PMID 26179012|