SKU: I043  / 
    CAS Number: 241479-67-4


    Isavoconazole is an Azol antifungal with broad-spectrum antifungal activity. It exhibits antifungal activity against most strains of Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger.  Isavuconazole is also effective against Mucorales such as Rhizopus oryzae, and Mucormycetes.
    Mechanism of ActionIsavuconazole disrupts the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. It inhibits the cytochrome P450-dependent enzyme lanosterol 14-alpha-demethylase, that mediates the conversion of lanosterol to ergosterol. Depletion of ergosterol within the fungal cell membrane leads to decreased structural integrity and function of the cell membrane.
    Molecular FormulaC22H17F2N5OS