Isavoconazole is an Azol antifungal with broad-spectrum antifungal activity. It exhibits antifungal activity against most strains of Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger. Isavuconazole is also effective against Mucorales such as Rhizopus oryzae, and Mucormycetes.
|Mechanism of Action||Isavuconazole disrupts the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. It inhibits the cytochrome P450-dependent enzyme lanosterol 14-alpha-demethylase, that mediates the conversion of lanosterol to ergosterol. Depletion of ergosterol within the fungal cell membrane leads to decreased structural integrity and function of the cell membrane.|