IT-143B is a rare, higher homolog of the piericidin class isolated from a Streptomyces sp. by Taiho Pharmaceuticals in
collaboration with Chinese researchers in 1996. IT-143B is active against the fungus, Aspergillus fumigatus, and the Gram-positive bacterium, Micrococcus luteus. IT-143B is also active against KB carcinoma cells. Lack of availability until now has hindered exploration of its pharmacological effects.
Urakawa A et al (1996) IT-143-A and B, novel piericidin-group antibiotics produced by Streptomyces sp. J. Antibiot. 49:1052