L-681217 is a glycolipid-type antibiotic related to the efrotomycin class, isolated from a Streptomyces sp.. L 681,217 shows broad spectrum antibiotic activity against Gram positive and Gram negative bacteria.
L-681217 is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
L-681217 is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
| Mechanism of Action | L-681217 inhibits bacterial protein synthesis at the elongation stage, its target being elongation factor Tu (EF-Tu). |
| References | Effects of elfamycins on elongation factor Tu from Escherichia coli and Staphylococcus aureus. Hall C.C. et al. Antimicrob. Agents Chemother. 1989, 33, 322. L-681,217, a new and novel member of the efrotomycin family of antibiotics. Kempf A.J. et al. J. Antibiot, 1986, 39, 1361. |
