Leoidin is a metabolite of the lichen, Lecanora gangleoides, first published in 1986 and recently reported as an inhibitor of
protein synthesis in Pseudomonas aeruginosa. Leoidin is bacteriostatic, targeting PheRS. Leoidin is a weak inhibitor of human HPGC (15-hydroxyprostaglandin dehydrogenase) and of sodium fluorescein uptake in OATP1B1- or OATP1B3-transfected CHO cells.
Devlin P et al (1986) Phytochemical examination of the lichen, Lecanora gangaleoides Nyl. Devlin J.P. et al., J. Chem. Soc., Perkin Trans.1, 1491-1494
Hu et al (2016) Discovery and analysis of natural-product compounds inhibiting protein synthesis in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 60:4820