Lincomycin is a lincosamide first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. This class of antibacterial contains a rare amino acid (4-propyl-N-methylprolin) coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin is often incorrectly considered an aminoglycoside but it actually shares little or no structural similarity. It is effective for Gram-positive bacteria and disrupts protein synthesis.
Lincomycin is soluble in ethanol, methanol, DMF and DMSO. Lincomycin is slightly soluble in water.
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|Application||Lincomycin can be used in biomedical applications in biocompatible compositive coatings to promote adhesion of osteoblast-like cells and prevent S. aureus biofilm development (Popescu-Pelin et al, 2018).|
|Mechanism of Action||Lincomycin binds to the 50S ribosomal subunit and blocks bacterial protein synthesis.|
|Spectrum||Lincomycin is effective against Gram-positive bacteria , and protozoans. It has been effective for Staphylococcus, Streptococcus, and Bacteroides fragilis.|
|Plant Biology Applications||Lincomycin provides a powerful plant selection agent that facilitates recovery of plastid transformants. Cultured Nicotiana cells were used in vitro. Resistant cells are green while sensitive cells are white on the selective medium (Moll et al, 1990).|
|Solubility||Soluble in ethanol, methanol, DMF or DMSO. Slightly soluble in water.|
Josten JJ and Allen PM (1964) The mode of action of Lincomycin. Biochem. Biophys. Res. Comm. 14(3):241-244 PMID 5836512
Mason D.J. et al. (1962) Lincomycin, a new antibiotic. I. Discovery and biological properties. Antimicrob. Agents Chemother. 1963:554
Mason DJ and Lewis C (1964) Biological activity of the lincomycin related antibiotics. Antimicrob. Agents Chemother. 10:7-12 PMID 14288036
Moll B, Polsby L and Maliga P (1990) Streptomycin and Lincomycin resistances are selective plastid markers in cultured Nicotiana cells. Mol. Gen. Genet. 221 (2):245-250