SKU: L014  / 
    CAS Number: 154-21-2

    Lincomycin

    $114.80 - $401.80

    Lincomycin is a lincosamide first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. This class of antibacterial contains a rare amino acid (4-propyl-N-methylprolin) coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin is often incorrectly considered an aminoglycoside but it actually shares little or no structural similarity.  It is effective for Gram-positive bacteria and disrupts protein synthesis.

    Lincomycin is soluble in ethanol, methanol, DMF and DMSO.  Lincomycin is slightly soluble in water.

    We also offer:

    • Lincomycin HCl, USP (L002)
    • Lincomycin HCl, EP (L016)
    ApplicationLincomycin can be used in biomedical applications in biocompatible compositive coatings to promote adhesion of osteoblast-like cells and prevent S. aureus biofilm development (Popescu-Pelin et al, 2018).
    Mechanism of ActionLincomycin binds to the 50S ribosomal subunit and blocks bacterial protein synthesis.
    SpectrumLincomycin is effective against Gram-positive bacteria , and protozoanas. It has been effective for Staphylococcus, Streptococcus, and Bacteroides fragilis.
    Plant Biology ApplicationsLincomycin provides a powerful plant selection agent that facilitates recovery of plastid transformants. Cultured Nicotiana cells were used in vitro. Resistant cells are green versus sensitive cells are white on the selective medium (Moll et al, 1990).
    Molecular FormulaC18H34N2O6S
    SolubilitySoluble ethanol, methanol, DMF or DMSO. Slightly soluble in water.
    References

    Josten JJ and Allen PM (1964)  The mode of action of lincomycin. Biochem. Biophys. Res. Comm. 14(3):241-244  PMID 5836512 

    Mason D.J. et al. (1962)  Lincomycin, a new antibiotic. I. Discovery and biological properties. Antimicrob. Agents Chemother. 1963:554

    Mason DJ and Lewis C (1964)  Biological activity of the lincomycin related antibiotics. Antimicrob. Agents Chemother. 10:7-12  PMID 14288036

    Moll B, Polsby L and Maliga P (1990)  Streptomycin and lincomycin resistances are selective plastid markers in cultured Nicotiana cells. Mol. Gen. Genet. 221 (2):245-250 

    Popescu-Pelin G et al (2018)  Lincomycin-embedded PANI-based coatings for biomedical applications. Appl. Surf. Sci. 455:653-666