Linezolid is an oxazolidinone antibiotic and is effective against Gram-positive bacteria including certain strains of methicillin-resistant Staphylococcus aureus (MRSA).
|Mechanism of Action||Linezolid inhibits protein synthesis by binding to the 50S ribosomal subunit (23S rRNA) which prevents formation of the 70S initiation complex thus inhibiting mRNA translation. It is also a monoamine oxidase inhibitor displaying nonselective, reversible binding.|
|Spectrum||Effective for Gram-positive bacteria including certain strains of MRSA|
|Eukaryotic Cell Culture Applications||Linezolid inhibits cytokine production from human peripheral blood monocytes in a dose-dependent manner. Linezolid was found to modify the acute phase inflammatory response. Linezolid inhibits cytokine production from human peripheral blood monocytes in a dose-dependent manner (Garcia-Roca et al, 2006).|
Ament PW (2002) Linezolid: Its role in the treatment of Gram-Positive, drug-resistant bacterial infections. Amer. Family Phys. 65(4):663-671