Malolactomycin C, produced by Streptomyces sp., is the N-demethyl analogue of the malolactomycin family, a 40-membered macrolide. Malolactomycin C has moderate activity against selected fungi, specifically Cladosporium, Botrytis, and Pyricularia. Its analogue, malolactomycin D, has been identified as a selective Ras signal inhibitor, preferentially inhibiting the anchorage-independent growth over anchorage-dependent growth of Ras-transformed NIH3T3 cells.
