SKU: M112  / 
    CAS Number: 189759-03-3

    Malolactomycin C

    $146.50 - $511.50

    Malolactomycin C, produced by Streptomyces sp., is the N-demethyl analogue of the malolactomycin family, a 40-membered macrolide. Malolactomycin C has moderate activity against selected fungi, specifically Cladosporium, Botrytis, and Pyricularia. Its analogue, malolactomycin D, has been identified as a selective Ras signal inhibitor, preferentially inhibiting the anchorage-​independent growth over anchorage-​dependent growth of Ras-​transformed NIH3T3 cells.

    Molecular Formula  C62H109N3O20

    Futamura M et al (2001)  Malolactomycin D, a potent inhibitor of transcription controlled by the Ras responsive element, inhibits Ras-​mediated transformation activity with suppression of MMP-​1 and MMP-​9 in NIH3T3 cells. Oncogene 20:6724

    Tanaka Y et al (1997)  Malolactomycins C and D, new 40-​membered macrolides active against Botrytis. J. Antibiot. 50:194