SKU: M051  / 
    CAS Number: 914-00-1

    Methacycline

    $124.50 - $432.50
    • Detailed Description

      CAS Number: 914-00-1

      Molecular Formula: C22H22N2O8

      Molecular Weight: 442.4

      Mechanism of Action: Like all tetracyclines, methacycline acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis.

      Storage Conditions: -20°C

    • Specifications

      Appearance: Yellow to orange solid

      Purity Level: >98% by HPLC

    • References

      References: 6-Methylenetetracyclines. I A new class of tetracycline antibiotics. Blackwood R.K. et al. J. Am. Chem. Soc. 1961, 83, 2773.

      6-Methylenetetracyclines. III. Preparation and Properties. Blackwood R.K. et al. J. Am. Chem. Soc. 1963, 85, 3943.

      A comparison of the in vitro and in vivo activity of methacycline and other tetracycline compounds. Chang T.W. & Weinstein L. Antibiot. Chemother. 1962, 12, 676.

      Evaluation of methacycline, a new analogue of oxytetracycline. Limson B.M. & Guevara R. Curr. Ther. Res. Clin. Exp. 1963, 5, 249.

    Methacycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of oxytetracycline to yield an exocyclic 6-methylene. Like all tetracyclines, methacycline shows broad spectrum antibacterial and antiprotozoan activity. Methacycline has been extensively cited in the literature with over 400 references.

    Methacycline is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number: 914-00-1

    Molecular Formula: C22H22N2O8

    Molecular Weight: 442.4

    Mechanism of Action: Like all tetracyclines, methacycline acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis.

    Storage Conditions: -20°C

    Appearance: Yellow to orange solid

    Purity Level: >98% by HPLC

    References: 6-Methylenetetracyclines. I A new class of tetracycline antibiotics. Blackwood R.K. et al. J. Am. Chem. Soc. 1961, 83, 2773.

    6-Methylenetetracyclines. III. Preparation and Properties. Blackwood R.K. et al. J. Am. Chem. Soc. 1963, 85, 3943.

    A comparison of the in vitro and in vivo activity of methacycline and other tetracycline compounds. Chang T.W. & Weinstein L. Antibiot. Chemother. 1962, 12, 676.

    Evaluation of methacycline, a new analogue of oxytetracycline. Limson B.M. & Guevara R. Curr. Ther. Res. Clin. Exp. 1963, 5, 249.