Midecamycin is an naturally occurring, broad-spectrum acetoxy-substituted macrolide antibiotic similar in structure to erythromycin. An acetoxy group is substituted on position 9 of the 16-membered ring and on position 4 of the terminal sugar. It is naturally produced by Streptomyces mycarofaciens. It interrupts protein synthesis of Gram-positive and Gram-negative bacteria. Its metabolites present little to no antimicrobial activity. It is very soluble in methanol, ethanol, and acidic solutions and soluble in DMSO.
