SKU: M058  / 
    CAS Number: 114177-14-9

    Milbemycin A3 oxime

    $266.16 - $931.59
    Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections.

    Milbemycin A3 oxime is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    Mechanism of ActionLike the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.
    ReferencesSynthesis of 5-keto-5-oxime derivatives of milbemycins and their activities against microfilariae. Tsukamoto Y. et al. Agric. Biol. Chem. 1991, 55, 2615.

    Effects of milbemycin on adult Toxocara canis in dogs with experimentally induced infection. Bowman D.D. et al. Am. J. Vet. Res. 1988, 49, 1986.