SKU: M057  / 
    CAS Number: 51596-10-2

    Milbemycin A3

    $324.39 - $1,135.35

    Milbemycin A3 belongs to the family of Milbemycins, 16-membered macrocyclic lactone antibiotics with a 6,6-membered spiroketal ring system.  Milbemycin A3 is a highly selective and potent nematocide and insecticide.  Milbemycin A3 is a major member of a group of analogs containing a 25-methyl substituent.  Milbemycin A3 is a metabolite derived from fermentation of the soil bacterium Streptomyces hydroscopicus subsp. aureolarcrimosus.  Milbemycins are analogs of the avermectins.  Other Milbemycins include Milbemycin B through H.

    Milbemycin A3 is soluble in ethanol, methanol, DMF and DMSO but has poor water solubility.

    We also offer:

    • Milbemycin A3 Oxime (M058)
    Mechanism of Action Like the closely related avermectins, Milbemycins are thought to act by opening glutamate sensitive and GABA-sensitive chloride channels.
    Spectrum Milbemycin A3 has activity against insects including mites, nematodes, worms, ticks, flights, and agricultural pests.
    Plant Biology Applications Milbemectin is used as an agri-chemical for crop protection in soft fruits, citrus fruit, top fruit, aubergines and others to combat mites and leaf miners.
    Insect Biology Applications

    Milbemectin is a GABA inhibitor and can act as an agonist of the RDL GABA receptor in Drosophila.


    Bi Z et al (2015)  Efficacy of four nematicides against the reproduction and development of pinewood nematode, Bursaphelenchus xylophilus. J. Nematol. 47(2):126-132  PMID 26170474

    Duke SO (2010)  Natural toxins for use in pest management. Toxins (Basel) 2(8):1943-1962  PMID 22069667

    Kornis GI (1995)  Avermectins and Milbemycins. In: Godfrey CRA, ed. Agrochemicals from natural products. Marcel Dekker. New York, NY  pp 215–255

    Nakao T, Banba  and Hirase K (2015)  Comparison between the modes of action of novel meta-diamide and macrycyclic lactone insecticides on the RDL GABA receptor. Pest. Biochem. and Physiol. 120:101-108   PMID 25987227

    Okazaki T et al (1983)  Milbemycins, a new family of macrolide antibiotics: Producing organism and its mutants J Antibiot. 36:438  PMID  6853372

    Takiguchi Y et al (1980) Milbemycins, a new family of macrolide antibiotics: Fermentation, isolation and physico-chemical properties. J Antibiot. 33:1120  PMID 7451362

    Takiguchi Y et al (1983)  Milbemycins, a new family of macrolide antibiotics. Fermentation, isolation and physico-chemical properties of Milbemycins D, E, F, G, and H. J Antibiot.(Tokyo). 36(5):502-508  PMID 6874568