Milbemycin A3 belongs to the family of Milbemycins, 16-membered macrocyclic lactone antibiotics with a 6,6-membered spiroketal ring system. Milbemycin A3 is a highly selective and potent nematocide and insecticide. Milbemycin A3 is a major member of a group of analogs containing a 25-methyl substituent. Milbemycin A3 is a metabolite derived from fermentation of the soil bacterium Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycins are analogs of the avermectins. Other Milbemycins include Milbemycin B through H.
Milbemycin A3 is soluble in ethanol, methanol, DMF and DMSO but has poor water solubility.
We also offer:
- Milbemycin A3 Oxime (M058)
|Mechanism of Action||Like the closely related avermectins, Milbemycins are thought to act by opening glutamate sensitive and GABA-sensitive chloride channels.|
|Spectrum||Milbemycin A3 has activity against insects including mites, nematodes, worms, ticks, flights, and agricultural pests.|
|Plant Biology Applications||Milbemectin is used as an agri-chemical for crop protection in soft fruits, citrus fruit, top fruit, aubergines and others to combat mites and leaf miners.|
|Insect Biology Applications||
Milbemectin is a GABA inhibitor and can act as an agonist of the RDL GABA receptor in Drosophila.
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