Mitoxantrone Dihydrochloride is used for cancer research as a chemotherapeutic for leukemias and solid tumors. It has immunosuppressive activity and inhibits proliferation of lymphocytes and induces apoptosis of antigen-presenting T-cells.
Mitoxantrone Dihydrochloride is sparingly soluble in water.
| Mechanism of Action | Mitoxantrone inhibits division of T-cells, B-cells, and macrophages by preventing DNA repair and synthesis, however, this also occurs in healthy cells. It is a cytostatic anthracenedione that induces double-strand breaks in DNA. |
| Cancer Applications | Mitoxantrone is commonly used in cancer research to study breast cancer, leukemia, and non-Hodgkin’s lymphoma. |
| Molecular Formula | C22H28N4O6 · 2 HCl |
| References |
Fox EJ (2004) Mechanism of action of Mitoxantrone. Neurol. 63(12 Suppl 6):S15-S18 PMID 15623664 |
