SKU: M105  / 
    CAS Number: 315-22-0

    Monocrotaline

    $154.35 - $540.23

    Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid derived from members of the Crotolaria species, long
    known to cause poisoining among livestock. Monocrotaline causes pulmonary artery hypertension, right ventricular
    hypertrophy, and pathological changes in the pulmonary vasculature in rats. Cardiopulmonary changes induced by
    monocrotaline are attenuated by treatment with oral magnesium. Monocrotaline is used in animal models of pulmonary arterial hypertension

    Molecular Formula  C16H23NO
    References

    Nogueira-Ferreira R et al (2015)  Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension. Pulm. Pharmacol. Ther. 35:8

    Schoental R and Head MA (1955) Pathological changes in rats as a result of treatment with monocrotaline.  Br. J. Cancer 9:229

    Xiao R et al (2017)  Monocrotaline induces endothelial injury and pulmonary hypertension by targeting the extracellular calciumsensing receptor. J. Am. Heart Assoc. 6 doi: 10.1161