Monomethylsulochrin is a benzophenone isolated from Aspergillus fumigatus by Turner, ICI Ltd in 1965. Monomethylsulochrin inhibits eosinophil degranulation. Its dimethyl analogue, sulochrin, inhibits VEGF leading to inhibition of capillary-like tube formation of human umbilical vein endothelial cells (HUVEC).
Lee HJ et al (2002) Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs J. Antibiot. 55:552
Ohashi H et et al (1999) Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation. Bioorg. Med. Chem. Lett. 9:1945
Turner B et al (1993) Identification of Ras farnesyltransferase inhibitors by microbial screening 6658