SKU: M109  / 
    CAS Number: 10056-14-1

    Monomethylsulochrin

    $185.22 - $648.27

    Monomethylsulochrin is a benzophenone isolated from Aspergillus fumigatus by Turner, ICI Ltd in 1965. Monomethylsulochrin inhibits eosinophil degranulation. Its dimethyl analogue, sulochrin, inhibits VEGF leading to inhibition of capillary-like tube formation of human umbilical vein endothelial cells (HUVEC).

    Molecular Formula  C18H18O
    References

    Lee HJ et al (2002)  Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs  J. Antibiot. 55:552

    Ohashi H et et al (1999)  Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation. Bioorg. Med. Chem. Lett. 9:1945

    Turner B et al (1993)  Identification of Ras farnesyltransferase inhibitors by microbial screening 6658