SKU: M070  / 
    CAS Number: 113507-06-5

    Moxidectin

    $109.73 - $384.02
    Moxidectin is a semi-synthetic milbemycin derived from nemadectin by selective oxidation followed by methyloximation. Moxidectin was patented in 1991 as an anthelmintic for internal parasite control. The presence of the methyloxime affords moxidectin a greater hydrophobicity and longer biological half-life compared to nemadectin.

    Moxidectin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
    Mechanism of ActionMoxidectin binds selectively to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
    ReferencesProcess for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds. Maulding D. R & Kumar A. US Patent 4,988,824 (1991).

    Moxidectin: a review of chemistry, pharmacokinetics and use in horses. Cobb R. & Boeckh. A. Parasites and Vectors 2009, 2 (Suppl 2) S5.