Mupirocin, USP is a carboxylic acid with bacteriostatic/bactericidal properties. This compound formerly known as pseudomonic acid A is produced by Pseudomonas fluorescens and is a naturally-occurring antibiotic with a broad-spectrum of activity against many Gram-positive bacteria and certain Gram-negative bacteria in vitro.
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Mupirocin is sparingly soluble in aqueous solution.
| Mechanism of Action | Mupirocin inhibits protein synthesis by binding to isoleucyl-tRNA synthetase, an enzyme which conjugates the amino acid isoleucine to its corresponding tRNA. |
| Spectrum | Mupirocin is commonly used to target Gram-positive bacteria especially methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) |
| Microbiology Applications | Mupirocin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive Staphylococcus microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
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| References |
Hatfield SM, Leyden JJ, and Parenti MI (1987) Mupirocin: A topical antibiotic with a unique structure and mechanism of action. 6(10):761-770 PMID 3146455 Masoud D, Hajikhani B, Darban-Sarokhalil D, van Belkum A, Goudarzi M (2020) Mupirocin resistance in Staphylococcus aureus: A systematic review and meta-analysis. J. Global Antimicrob. Res. 20:238-247 |
| MIC | Enterococcus faecalis| 51.38 － 64|| Enterococcus faecium| 1 － 12.5|| Escherichia coli| 0.05 － 0.2|| Haemophilus influenzae| ≤0.016 － 0.25|| Moraxella catarrhalis| 0.5 － 4|| Salmonella typhimurium| 16 － >1024|| Staphylococci| 0.06 － 1024|| Staphylococcus aureus| 0.006 － 4096|| Staphylococcus auricularis| ≤2 － >256|| Staphylococcus capitis| ≤2 － >2556|| Staphylococcus epidermidis| 0.06 － >256|| Staphylococcus haemolyticus| ≤2 － >256|| Staphylococcus hominis| ≤2 － >256|| Staphylococcus intermedius| ≤2 － >256|| Staphylococcus lugdunensis| ≤2 － >256|| Staphylococcus pyogenes| ≤2|| Staphylococcus saprophyticus| 0.06 － >256|| Staphylococcus simulans| ≤2 － >256|| Staphylococcus spp.| ≤4 － >128|| Staphylococcus warneri| ≤2 － >256|| Streptococci| 0.25 － >16|| Streptococcus agalactiae| 0.25 － ≤4|| Streptococcus pneumonia| 0.1 － 4|| Streptococcus pyogenes| 0.06 － >16|| |
