Nadifloxacin is a fluorinated fluoroquinolone antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, especially Propionibacterium acnes. It also shows antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Nadifloxacin is capable of treating green nail syndrome caused by Pseudomonas aeruginosa.
|Mechanism of Action||Nadifloxacin inhibits Topo II (DNA gyrase) in Gram-negative bacteria, and Topo IV in Gram-positive bacteria, which both function to relax positive supercoils prior to DNA replication, thus inhibiting bacterial multiplication.|
|Spectrum||broad-spectrum activity against Gram-positive and Gram-negative bacteria.|
|Solubility||DMSO (20 mg/ml) @ 25°C) water (<1 mg/ml @ 25°C), ethanol (<1 mg/ml @ 25°C).|
|References||Narayanan V et al (2014) Efficacy and safety of nadifloxacin for bacterial skin infections: Results from clinical and post-marketing studies. Dermatol. Ther. 4:233-248 Müller S (2014) Green nail syndrome (Pseudomonas aeruginosa nail infection): Two cases successfully treated with topical Nadifloxacin, an acne medication. Case Rep. Dermatol. 6:180-184.|