Nafamostat Mesylate is a synthetic serine protease inhibitor, inhibiting a number of Lys/Arg-specifc serine proteinases. It is a tryptase inhibitor. It is an anticoagulant. proventing the proteolysis of fibrinogen into fibrin. The compound has anti-viral, anti-inflammatory, and anti-cancer properties.
Nafamostat Mesylate has potential for COVID-19 research as it has potent in vitro anti-viral inhibitor in lung cells. A number of phase 2 and 3 clinical trials are underway in several countries.
