The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine H is an acylated drimane which is a putative biosynthetic intermediate of the higher nanagenines. Nanangenine H is inactive against B. subtilis (IC50 >100 μg/mL) and modestly active against NS-1 cell line (IC50 47 μg/mL). The nanangenines did not exhibit Gram negative, antibacterial, antifungal or herbicidal activity.
Lacey HJ et al (2019) Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Beilstein J Org Chem. 15:2631