Nargenicin (CP-47,444) is a 10-membered macrocyclic lactone isolated from Nocardia in 1980 as an antibiotic. The macrocyclic lactone is anchored through vicinal carbons to a decalin bearing a pyrrole ester. Nargenicin exhibits potent activity against Gram positive bacteria, in particular MRSA strains. More recently, nargenicin has been shown to enhance retinoate-induced cell differentiation.
Nargenicin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Nargenicin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.