Nystatin is a fungicidal and fungistatic polyene antifungal and growth promoter, first reported in 1950. It is a complex of three components: A1, A2 and A3. Nystatin functions by accumulating cholesterol and thereby sequesters lipid from cell membranes. It can be used as a bioprobe and widely used antifungal. It can also be used in quantum dot research, since cholesterol depletion can block several lipid raft-dependent endocytic pathways.
Nystatin A1 is soluble in DMF and DMSO, moderately soluble in methanol and ethanol, and sparingly soluble in water.
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