Ophiobolin C is a member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus Bipolaris.
Ophiobolin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Ophiobolin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Mechanism of Action | Ophiobolin C inhibits human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 entry into cells. Blockade of this binding was considered by scientists at Merck as a potential new mode of action for the treatment of HIV-1 infection. |
| References | The structure of zizannin-A and -B, C25-terpenoids isolated from Helminthosporium zizaniae. Nozoe S. et al. , Tetrahedron Lett. 1966, 7, 2211. Isolation and structure of antagonists of chemokine receptor (CCR5). Jayasuriya et al. , H. J. Nat. Prod. 2004, 67, 1036. The biology of ophiobolins. Au T.K. et al. , Life Sci. 2000, 67, 733. (Review). |
