Orfamide A is the major component of a family of cyclic lipopeptides produced by Pseudomonas fluorescens, reported in 2007. The orfamides were discovered by employing genomic analysis with an isotope-guided fractionation to identify metabolites produced by orphan gene clusters containing non-ribosomal peptide synthetases. Orfamide A has received scant investigation of its bioprofile but appears to be a selective antifungal agent. Uniquely, orfamide A lyses zoospores of the oomycete, Phytophthora ramorum, the cause of sudden oak death. Orfamide A has a profound effect on the swarming motility of bacteria on agar surfaces.
Orfamide A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Orfamide A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Molecular Formula | C64H114N10O17 |
| Documents | The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. Gross H. et al. Chem Biol. 2007, 14, 53. |
