Oritavancin is a semi-synthetic vancomycin analogue active against Gram-positive bacteria. It has a secondary mode of action that allows it to remain active against vancomycin-resistant organisms. It is rapidly bactericidal and effective at killing biofilm-producing pathogens like MRSA and VRE.
Oritavancin diphosphate is soluble in water.
|Mechanism of Action||Like other glycopeptides and lipoglycopeptides, oritavancin inhibits transglycosylation to stop peptidoglycan synthesis. |
Its secondary mode of action is to interact directly with the cell membranes, causing depolarization which permeabilizes the membrane and causes cell death.
|Molecular Formula||C86H97Cl3N10O26 · 2H3PO4|
|References||Zhanel, G. G., Schweizer, F., & Karlowsky, J. A. (2012). Oritavancin: Mechanism of action. Clinical Infectious Diseases, 54(suppl 3), S214–S219. doi:10.1093/cid/cir920|