Oxymatrine is an alkaloid extracted from Sophora spp. It has shown antifibrotic and neuroprotective properties, and in the last five years has been studied for its anti-HBV activity. Its antiviral properties were studied due to its use in traditional Chinese medicine. It is very similar in structure to Matrine (M075).
| Mechanism of Action | The antiviral mode of action of oxymatrine has not yet been proven, though there have been multiple studies. |
| Molecular Formula | C15H24N2O2 |
| References | Wang, Y.-P., Zhao, W., Xue, R., Zhou, Z.-X., Liu, F., Han, Y.-X., … Jiang, J.-D. (2011). Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance. Antiviral Research, 89(3), 227–231. doi:10.1016/j.antiviral.2011.01.005 Xu, W.-S., Zhao, K.-K., Miao, X.-H., Ni, W., Cai, X., Zhang, R.-Q., & Wang, J.-X. (2010). Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro. World Journal of Gastroenterology : WJG, 16(16), 2028–2037. http://doi.org/10.3748/wjg.v16.i16.2028 |