Paclitaxel (Taxol) is a unique anti-tumor agent derived from the bark of the Pacific Yew tree. The molecule consists of a complex diterpene with a taxane ring. It is a potent anti-neoplastic and anti-mitotic compound.
Pacitaxel is sparingly soluble in ethanol, DMSO, and DMF.
|Mechanism of Action||Paclitaxel has a unique mechanism of action. In vitro, it enhances tubulin polymerization to stablize microtubules againse cold- and calcium-induced depolymerization. It is unique among chemotherapeutic agents, polymerizing tubulin in the absence of cofactors. Paclitaxel prevents tumor growth by stabilizing microtubules during mitosis in the G2/M growth phase leading to cell death.|
|Cancer Applications||Paclitaxel can be used to study effects on actively dividing tumor cells.|
Fiser A et al (2006) Insights into the mechanism of microtubule stabilization by Taxol. PNAS 103(27): 10166-10173
Horwitz SB (1994) Taxol (paclitaxel): Mechanisms of Action. Ann. Oncol 5 Suppl 6:S3-6 PMID 7865431