SKU: P151  / 
    CAS Number: 159934-11-9

    Palmarumycin C3

    $164.50 - $575.50

    The palmarumycins are fungal metabolites isolated from Coniothyrium and Sphaeropsidales sp. with antifungal, antibacterial, antitumor and herbicidal properties. Palmarumycin C3 is a yellow-green pigment which inhibits Ras farnesyl-protein transferase. Palmarumycin C3 is a more potent antimicrobial agent against A. tumefaciens, B. subtilis, P. lachrymans, R. solanacearum, S. haemolyticus, X. vesicatoria and M. oryzae than its dehydroxy analog palmarumycin C2, with MICs in the range of 6 – 13 µg/mL. Palmarumycin C3 is a weak inhibitor of spore germination of M. oryzae and a modest antioxidant in DPPH radical scavenging and β-carotene/linoleic acid bleaching capacity assays.

    Molecular Formula  C20H12O6

    Krohn K et al (1994)  Palmarumycins C1-​C16 from Coniothyrium sp.: isolation, structure elucidation, and biological activity. Liebigs Annalen der Chemie 11:1099

    Mou Y et al (2013)  Antimicrobial and antioxidant activities and effect of 1-​hexadecene addition on palmarumycin C2 and C3 yields in liquid culture of endophytic fungus Berkleasmium sp. Dzf12. Molecul. 18:15587

    Powis G et al (2006)  Molecular pharmacology and antitumor activity of palmarumycin-​based inhibitors of thioredoxin reductase. Mol Cancer Therap. 5: 630.