Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic.
Paraherquamide A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Paraherquamide A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Mechanism of Action | Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors. |
| Molecular Formula | C28H35N3O5 |
| References | The structure of parherquamide, a toxic metabolite from Penicillium paraherquei. Yamazaki M.E. et al. Tetrahedron Lett. 1982, 22, 135. Novel antinematocidal and antiparasitic agents from Penicillium charlesii I. Fermentation, isolation and biological activity. Ondeyka J.G. J. Antibiot. 1990, 43, 1375. Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle. Robertson A.P. et al. J. Pharmacol. Exp. Ther. 2002, 302, 853. |
