SKU: P147  / 
    CAS Number: 1214268-60-6

    Penicinoline

    $218.50 - $761.50
    • Detailed Description

      CAS Number: 1214268-60-6

      Molecular Formula: C14H10N2O3  

      Molecular Weight: 254.2

      Tariff Code: 3822.00.5090

    • Specifications

      Form: Solid

      Appearance: Yellow solid

      Source: Penicillium spp.

    • Technical Data

      Solubility: Soluble in ethanol, methanol, DMF or DMSO.

    • References

      References:

      Shao C-L et al (2010)  Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg. Med. Chem. Lett. 20:3284

      Nand M et al (2016)  Virtual screening of natural compounds as inhibitors of EGFR 696-1022 T790M associated with non-small cell lung cancer. Bioinform. 12:311

    Penicinoline is an unusual quinolinone alkaloid isolated from a mangrove endophytic Penicillium species by researchers at the Key Laboratory of Marine Drugs in collaboration with Syngenta and first reported in 2010. Penicinoline posseses broad
    spectrum insecticidal activity and potent cytotoxic activity. In silico screening indicates that penicinoline inhibits EGFR 696-1022 T790M associated with non-small cell lung cancer.

    CAS Number: 1214268-60-6

    Molecular Formula: C14H10N2O3  

    Molecular Weight: 254.2

    Tariff Code: 3822.00.5090

    Form: Solid

    Appearance: Yellow solid

    Source: Penicillium spp.

    Solubility: Soluble in ethanol, methanol, DMF or DMSO.

    References:

    Shao C-L et al (2010)  Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg. Med. Chem. Lett. 20:3284

    Nand M et al (2016)  Virtual screening of natural compounds as inhibitors of EGFR 696-1022 T790M associated with non-small cell lung cancer. Bioinform. 12:311