Penicinoline is an unusual quinolinone alkaloid isolated from a mangrove endophytic Penicillium species by researchers at the Key Laboratory of Marine Drugs in collaboration with Syngenta and first reported in 2010. Penicinoline posseses broad
spectrum insecticidal activity and potent cytotoxic activity. In silico screening indicates that penicinoline inhibits EGFR 696-1022 T790M associated with non-small cell lung cancer.
Shao C-L et al (2010) Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg. Med. Chem. Lett. 20:3284
Nand M et al (2016) Virtual screening of natural compounds as inhibitors of EGFR 696-1022 T790M associated with non-small cell lung cancer. Bioinform. 12:311