PGLa is an antimicrobial peptide (AMP) composed of 21 amino acids which form an α-helical secondary structure. Like many AMPs PGLa exerts a wide variety of antimicrobial activity including activity against fungi, viruses, gram-negative and gram-positive bacteria, and cancer cell lines.
|Mechanism of Action||PGLa can dimerize and insert into cellular membrane, where the dimers assemble into a transmembrane pore structure.|
|References||Hartmann, M., Berditsch, M., Hawecker, J., Ardakani, M. F., Gerthsen, D., & Ulrich, A. S. (2010). Damage of the Bacterial Cell Envelope by Antimicrobial Peptides Gramicidin S and PGLa as Revealed by Transmission and Scanning Electron Microscopy. Antimicrobial Agents and Chemotherapy, 54(8), 3132-3142. doi:10.1128/aac.00124-10|
Strandberg, E., Tremouilhac, P., Wadhwani, P., & Ulrich, A. S. (2009). Synergistic transmembrane insertion of the heterodimeric PGLa/magainin 2 complex studied by solid-state NMR. Biochimica Et Biophysica Acta (BBA) - Biomembranes, 1788(8), 1667-1679. doi:10.1016/j.bbamem.2008.12.018