SKU: P088  / 
    CAS Number: 78822-40-9

    Pirlimycin Hydrochloride

    $173.70 - $607.95

    Pirlimycin Hydrochloride is the hydrochloride salt form of Pirlimycin, a semi-synthetic tetracycline analog and derivative of clindamycin, a broad-spectrum antibiotic belonging to the lincosamide family, which has activity against anaerobes and protozoa.  The hydrochloride salt forms at the basic pipercolic acid moiety. 

    Pirlimycin Hydrochloride is soluble in ethanol, methanol, DMF and DMSO.

    Molecular Formula C17H31Cl1N2O5S • HCl
    Spectrum Pirlimycin Hydrochloride is active against Gram-positive and Gram-negative bacteria including Staphylococcus and Streptococcus.  It is also active against anaerobic bacteria and protozoa.
    Mechanism of Action

    Pirlimycin binds to the 23S ribosomal subunit, blocking protein synthesis. 


    Ahonkhai VI et al (1982) In vitro activity of U-57930E, a new Clindamycin analog, against aerobic Gram-positive bacteria. Antimicrob. Agents Chemother. 21:902 

    Birkenmeyer RD et al (1984)  Synthesis and antimicrobial activity of Clindamycin analogs: Pirlimycin, 1,2 a potent antibacterial agent. Med. Chem. 27:216