SKU: P091  / 
    CAS Number: 125-65-5

    Pleuromutilin

    $277.35 - $970.71
    Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action.

    Pleuromutilin is soluble in ethanol, methanol, DMF and DMSO.
    Mechanism of ActionPleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.
    ReferencesAntibiotic substances from basidomycetes. VIII. Pleurotus mutilus (Fr.) Sacc. & Pleurotus passeckerianus Pilat. Kavanagh F. et al. , Proc. Natl. Acad. Sci. USA 1951, 37, 570.

    Pleuromutilin antibiotics. Hunt E., Drugs Future 2000, 25, 1163.

    Pleuromutilins. Part 1. The indentification of novel mutilin 14-carbamates. Brooks G. et al. , Bioorg. Med. Chem. 2001, 9, 1221.