Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile, by Taylor and Ritchie in 1970. More recently, Pluviatolide and the related hinokinin were reported as metabolites of the vine, Aristolochia constricta, and subsequently other genus. Pluviatolide exhibits antispasmodic effects, however its pharmacology has received little attention.