Pneumocandin B0 is the major analogue of a family of lipopeptides isolated from some species of Cryptosporiopsis, Glarea and Pezicula.
Pneumocandin B0 is soluble in ethanol, methanol, DMF and DMSO.
Pneumocandin B0 is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Pneumocandin B0 is a potent antifungal and acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi. |
| Molecular Formula | C50H80N8O17 |
| References | 671,329, a new antifungal agent I. Fermentation and isolation. Schwartz R. E. et al. J Antibiot. 1989, 42, 163. 671,329, a new antifungal agent II. Structure determination Wichmann C. F. et al. J Antibiot. 1989, 42, 168. L-671,329, a new antifungal agent. III. In vitro activity, toxicity and efficacy in comparison to aculeacin. Fromtling R. A. & Abruzzo G. K. J. Antibiot. 1989, 42, 168. |