Ponazuril is an antiprotozoal agent, specifically a triazine anticoccidial used in veterinary pharmacological research. It is effective against the apicomplexan group of organisms. It was originally developed to treat Sarcocystis neurona infections in horses, a parasite causing a neurological disease known as equine protozoal myeloencephalitis (EPM). It has also shown effectiveness against Theileria equi, and Toxoplasma gondii.
|Mechanism of Action||Ponazuril, a coccidiostat, are active against the plastic body of the parasite, and inhibit replication of the single-celled parasites|
|Spectrum||Effective against protozoa including Sarcocystis neurona, Theileria equi, Toxoplasma gondii,|
|References||Mackay RJ, Tanhauser ST, Gillis KD, Mayhew IG, Kennedy TJ (2008) Effect of intermittent oral administration of ponazuril on experimental Sarcocystis neurona infection of horses. Am J Vet Res 69(3):396-402 PMID 18312139 Martínez-Villalba A, Moyano E, Martins CP, Galceran MT (2010) Fast liquid chromatography/tandem mass spectrometry (highly selective selected reaction monitoring) for the determination of toltrazuril and its metabolites in food. Anal Bioanal Chem. 397(7):2893-901 PMID 20658773 Mitchell SM, Zajac AM, Davis WL and Lindsay DS (2003) Mode of action of panazuril against Toxoplasma gondii tachyzoites in cell culture. J. Euk. Microbiol. 50:689-690 PMID 14736221 Mitchell SM, Zajac AM, Davis WL and Lindsay DS (2004) Efficacy of Ponazuril in vitro and in preventing and treating Toxoplasma gondii infections in mice. J. Parasitol. 90(3):639-642 PMID 15270113 Wise LN et al (2012) In vitro activity of ponazuril against Theileria equi. Vet Parasitol. 185(2-4):282-285. PMID 22130334|