Praziquantel is an anti-helminthic that causes contractions and paralysis in non-resistant organisms. Research suggests praziquantel works mostly by increasing cell permeability.
|Mechanism of Action||Praziquantel increases the permeability of the tegmentum to Ca2+ inducing paralytic muscle contraction and death. Recent studies have indicated that praziquantel binds to a variant of the β- subunit of the voltage gated Ca2+ channel and to actin, which is a component of some Ca2+ channels.|
|Eukaryotic Cell Culture Applications||Praziquantel is a potent anthelmintic against parasitic flatworms (flukes and tapeworms).|