Pyridomycin is a potent antibiotic active against mycobacteria and some Gram negative bacteria, originally isolated from Streptomyces abidoflavus by Umezawa group at the NIH Japan in 1953, and since isolated from different species and published under several names. The unusual 12-membered macrocyclic depsipeptide comprises three unique sub-units incorporating two substituted pyridines. Recent reports of activity against isoniazid-resistant mycobacteria has seen pyridomycin identified as a potential lead for new generation antibiotics.
Pyridomycin is soluble in ethanol, methanol, DMF and DMSO.
Pyridomycin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Pyridomycin is thought to target NADH-dependent enoyl (acyl-carrier-protein) reductase InhA. |
| Molecular Formula | C27H32N4O8 |
| References | A new antibiotic, pyridomycin. Maeda K. et al. J. Antibiot. 1953, 6, 140. Towards a new tuberculosis drug: pyridomycin – nature’s isoniazid. EMBO Mol. Med. 2012, 4, 1032. |