Pyripyropene A is a meroterpenoid isolated from Aspergillus fumigatus and published in 1993 by Omura and co-workers at the Kitasato Institute, Japan. Pyripyropene A has potent acyl-CoA:cholesterol acyltransferase (ACAT) and the isozyme sterol Oacyltransferase 2 (SOAT2) inhibitory activity, thus inhibiting the conversion of cholesterol to cholesteryl esters. Pyripyropene A is active against aphids in field trials and has weak insect anti-feedant activity.
Kim YK et al (1994) Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes journal 47:154
Ohtawa M et al (2018) Design and synthesis of A-ring simplified pyripyropene A analogues as potent and selective synthetic SOAT2 inhibitors. Chem. Med. Chem. 13:411
Omura et al (1996) Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigata 46:1168