Quinolactacin A1 is the dominant analogue of a family of quinolone metabolites produced by Penicillium citrinum. Quinolactacin A1 rapidly epimerises to equilibrate with its diastereomer quinolactacin A2 in protic solvents. The mixture has been shown to inhibit acetylcholinesterase and TNF production.
Quinolactacin A1 is soluble in ethanol, methanol, DMF and DMSO.
Quinolactacin A1 is soluble in ethanol, methanol, DMF and DMSO.
| Molecular Formula | C16H18N2O2 |
| References | Biosynthesis of quinolactacin A, a TNF production inhibitor. Sasaki T. et al. J Antibiot. 2006, 59, 418. Quinolactacins A1 and A2, new acetylcholinesterase inhibitors from Penicillium citrinum. Kim W.G. et al. J Antibiot. 2001, 54, 831. Quinolactacins A, B and C: novel quinolone compounds from Penicillium sp. EPF-6. I. Taxonomy, production, isolation and biological properties. Kakinuma N. et al. J Antibiot. 2000, 53,1247. Clark B. et al. Quinolactacins revisited: from lactams to imides and beyond. Org Biomol Chem. 2006, 4, 1512. |
