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Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp.. Gilvocarcin V contains a vinyl group in the 8-position, and is the most potent...
Quinomycin A is a cyclic depsipeptide metabolite. Quinomycin A has broad activity against bacteria, fungi and viruses, and has found application as an antitumor agent. Quinomycin A acts by...
Quinaldopeptin is a symmetrical, cyclic decapeptide from an Amycolatopsis sp. that is a bis-intercalator of DNA, exhibiting strong in vitro antimicrobial and cytotoxic activity. Quinaldopeptin...
Venturicidin B (Aabomycin A2) is a 20-member macrolide glycoside compound that was originally isolated from a Streptomyces sp.by Glaxo Labs in 1961. Venturicidin B is a potent antifungal and toxic...
Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumor activity...
Temsirolimus is a semisynthetic macrocyclic lactone prepared from Rapamycin. It is a dihydroxymethyl propionic acid ester and analog of Rapamycin. The compound is prepared by selective acylation of...
Cytochalasin A is one of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced...
Ixazomib Citrate is a prodrug of ixazomib, a protease inhibitor used in cancer research when studing multiple myleoma. When in its biologically active form, ixazomib can inhibit angiogensis and...
Terrecyclic acid is a tricyclic sesquiterpene antibiotic produced by Aspergillus terreus, first reported by researchers at the Universities of Osaka and Tokyo in 1982. Terrecyclic acid A had a wide...
Leucinostatin A is the major component of an atypical nonapeptide complex produced by Paecilomyces lilacinus, first reported in 1973. Leucinostatins display broad bioactivity against Gram-positive...
Cytochalasin C is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic...
Sultriecin is the dominant analogue in a family of triene antibiotics originally thought to be sulfate esters, but recently unequivocally proven to be phosphate esters. While re-naming of the...