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Dasatinib is multitarget kinase inhibitor used in the treatment of leukemia. Dasatinib's main targets are tyrosine kinase BCR/ABL, which works to provide the cancer cell with ATP at an uncontrolled rate causing rapid division, and the SRC family of...
Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum.Epothilone B is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.Mechanism of ActionEpothilone B acts by stabilising microtubule formation at the...
Oligomycin E (26-hydroxyoligomycin B) is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes. ...
19,20-Epoxycytochalasin C is a major component of the cytochalasin complex. Although reported in the literature, there is no available biological data on the metabolite other than in-house data suggesting the presence of the epoxide renders the...
Citreoviridin is the dominant analogue of a family of tetraene mycotoxins with potent neurotoxic effects, produced by several species of Aspergillus and Penicillium. Citreoviridin inhibits mitochondrial ATPase and is a causative agent of cardiac beriberi...
19,20-Epoxycytochalasin D is a major component of the cytochalasin complex. Although reported in the literature, there is no available biological data on the metabolite other than in-house data suggesting the presence of the epoxide renders the...
Imatinib mesylate is a tyrosine kinase inhibitor used primarily in the treatment of leukemia. Chronic Myeloid Leukemia (CML) cells contain a hybrid tyrosine kinase BCR/ABL that works to provide the cancer cell with ATP at an uncontrolled rate. Imatinib...
Nisin (Nisin A) is a natural bacteriocin polypeptide antibiotic known as a lantibiotic. It is a 34-amino acid polycyclic antibacterial peptide. It was isolated in the late 1930s from Lactococcus lactis. Nisin A and Nisin Z are two...
21-Hydroxyoligomycin A is a rare member of the Oligomycin class, isolated as a co-metabolite of nemadectin, hence it was originally named Nemadectin omega. Only limited literature references are available. In-house testing suggests that...
Fostriecin is the most fully characterised member of a family of phosphate esters of a triene antibiotic. The antitumor potential of Fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent...
Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. It reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.Fumitremorgin C is soluble in ethanol, methanol, DMF or...
Oligomycin A is a dominant analog of the Oligomycin class of macrocyclic lactones isolated from selected strains of Streptomyces sp. The class includes the analogs/isomers A through G. Different isomers are highly specific for the disruption of...
