Antitumor

Trichostatin C

Trichostatin C is the first example of a glucopyranosyl hydroxamate from nature. The conjugation may act to protect the less stable N-OH group of Trichostatin A. Trichostatin C displays antifungal, antiprotozoan and antitumor activity, albeit less potent...

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Bestatin

Bestatin is 'pseudo'-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin also exhibits antitumor activity and has been investigated in clinical trials...

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Filipin

Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of...

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Ridaforolimus

Ridaforolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a dimethylphosphinate moiety. Ridaforolimus is extensively cited in the literature with over 70 citations.Ridaforolimus is...

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Cerulenin

Cerulenin is an epoxy fatty acid amide isolated from the fungus Cephalosporium caerulens identified as an antifungal in the 1960s. Over the past 40 years, cerulenin has found broad application in lipid biochemistry as an inhibitor fatty acid and sterol...

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Filipin II

Filipin II is a minor component of the filipin complex, a family of pentaene antifungal metabolites first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Structurally, filipin II lacks the hydroxy moiety on the...

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Filipin III

Filipin III is the major component of the filipin complex, a family of pentaene antifungal metabolites first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin III is a potent broad spectrum antifungal agent...

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Calphostin C

Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides and inhibits cell proliferation and induces apoptosis in vitro.Calphostin C is soluble in ethanol, methanol, DMF and DMSO.Mechanism of...

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Lenalidomide

Lenalidomide is an analogue of the immunomodulatory drug thalidomide with increased potency and fewer adverse effects. It is used in the treatment of hematologic and solid cancers due to its antitumor and anti-angiogenic activities.Mechanism of...

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Neoaureothin

Neoaureothin is an unusual chain-extended analogue of aureothin. Neoaureothin was first reported as a co-metabolite of neoantimycin in Streptomyces orinoci. Neoaureothin has anti-HIV and antifungal activity. Recent investigations have identified two...

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Chartreusin

Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. Chartreusin is also a potent inhibitor of topoisomerase II.Chartreusin is soluble ethanol, methanol, DMF and DMSO.Mechanism of...

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Clarithromycin related compound H, EvoPure®

Clarithromycin related compound H, EvoPure® (3″-N-demethyl-3′-N-formyl-6-Omethylerythromycin A) is a highly purified impurity found in Clarithromycin that can be used as a reference standard. We also offer: Clarithromycin, USP...

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