Immunosuppressants

Mycophenolic Acid

Mycophenolic Acid is an antimetabolite and an active metabolite of Mycophenolate mofetil.  It can inhibit DNA synthesis of T and B lymphocytes via selective inhibition of inosine monophosphate dehydrogenase.  It also acts as an...

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Tetramisole hydrochloride

Tetramisole hydrochloride (levamisole, ergamisol) is an alkaline phosphatase inhibitor with antihelminthic and anticancer properties.  Mechanism of Action Tetramisole HCl inhibits parasitic worm growth by acting as an agonist to nicotinic...

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Mizoribine

Mizoribine is an imidazole nucleoside which acts as an immunosuppressant by inhibiting lymphocyte proliferation. Mizoribine is freely soluble in water (20 mg/mL).Mechanism of ActionMizoribine inhibits inosine monophosphate synthetase and guanosine...

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Conglobatin

Conglobatin is a unique dimeric macrolide antibiotic derived from ionomycin, an ionophore produced by Streptomyces conglobatus. Conglobatin is soluble in ethanol, methanol, and DMSO.Mechanism of ActionMacrolide antibiotics inhibit bacterial growth by...

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FK-506

FK-506, also known as Tacrolimus, is a macrolide immunosuppressive drug commonly used post-transplant to reduce graft rejection. FK-506 is insoluble in aqueous solution. This product is considered a dangerous good. Quantities above 1 g may be subject to...

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Cyclosporin H, EvoPure®

Cyclosporin H, EvoPure® is a hydroxylated metabolite of Cyclosporin A.  Cyclosporin H (M-1) and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressant activity than Cyclosporin A.   Cyclosporin H has...

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Cyclosporin A, EvoPure®

Cyclosporin A, EvoPure® is a neutral, cyclic oligopeptide with immunosuppressive activity.  Cyclosporin A has the most potent immunosuppressive activity of the metabolites (Cyclosporin B, C, D, E, and H).  Cyclosporin A has been used to...

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Cyclosporin D, EvoPure®

Cyclosporin D, EvoPure® is a hydroxylated metabolite of Cyclosporin A.  Cyclosporin D and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressant activity than Cyclosporin A.  Cyclosporin D has been found to...

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Cyclosporin C, EvoPure®

Cyclosporin C, EvoPure® is a hydroxylated metabolite of Cyclosporin A.  Cyclosporin C has similar immunosuppressant activity, but lower nephrotoxicity than Cyclosporin A.  Cyclosporin C also has antimycotic properties. EvoPure® products...

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Cyclosporin B, EvoPure®

Cyclosporin B, EvoPure® is the dihydroxylated metabolite of Cyclosporin A.  Cyclosporin B (M-26) and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressive activity compared Cyclosporin A.  Cyclosporin B and...

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Ascomycin

Ascomycin is an ethyl analog of FK506 with strong immunosuppressant properties.Mechanism of ActionAscomycin inhibits the production of cytokines produced by Th1 and Th2 cells namely IL-2, IL-4, and IL-10. Additionally, ascomycin inhibits mast cell...

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Rapamycin

Rapamycin (Sirolimus) is a natural compound belonging to the macrolide family.  It is derived from Streptomyces hygroscopicus isolated from a soil sample from Easter Island in 1972 by Mr. Sehgal of Ayerst Research Labs in Montreal, Quebec...

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