Mycophenolic Acid is an antimetabolite and an active metabolite of Mycophenolate mofetil. It can inhibit DNA synthesis of T and B lymphocytes via selective inhibition of inosine monophosphate...
Mizoribine is an imidazole nucleoside which acts as an immunosuppressant by inhibiting lymphocyte proliferation. Mizoribine is freely soluble in water (20 mg/mL).Mechanism of ActionMizoribine...
Conglobatin is a unique dimeric macrolide antibiotic derived from ionomycin, an ionophore produced by Streptomyces conglobatus. Conglobatin is soluble in ethanol, methanol, and DMSO.Mechanism of...
FK-506, also known as Tacrolimus, is a macrolide immunosuppressive drug commonly used post-transplant to reduce graft rejection. FK-506 is insoluble in aqueous solution. This product is considered a...
Cyclosporin H, EvoPure is a hydroxylated metabolite of Cyclosporin A. Cyclosporin H (M-1) and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressant activity than...
Cyclosporin A, EvoPure is a neutral, cyclic oligopeptide with immunosuppressive activity. Cyclosporin A has the most potent immunosuppressive activity of the metabolites (Cyclosporin B, C, D, E, and...
Cyclosporin D, EvoPure is a hydroxylated metabolite of Cyclosporin A. Cyclosporin D and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressant activity than Cyclosporin...
Cyclosporin C, EvoPure is a hydroxylated metabolite of Cyclosporin A. Cyclosporin C has similar immunosuppressant activity, but lower nephrotoxicity than Cyclosporin A. Cyclosporin C also has...
Cyclosporin B, EvoPure is the dihydroxylated metabolite of Cyclosporin A. Cyclosporin B (M-26) and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressive activity...
Ascomycin is an ethyl analog of FK506 with strong immunosuppressant properties. Mechanism of Action Ascomycin inhibits the production of cytokines produced by Th1 and Th2 cells namely IL-2, IL-4,...
Rapamycin (Sirolimus) is a natural compound belonging to the macrolide family. It is derived from Streptomyces hygroscopicus isolated from a soil sample from Easter Island in 1972 by Mr. Sehgal of...
Cyclosporine, USP (syn: Cyclosporin,Cyclosporin A) is a natural product and cyclic polypeptide derived from fungi. It is a macrolide with potent immunosuppressive properties. Cyclosporine was...
