Simvastatin is semi-synthetic, slightly more hydrophobic analog of lovastatin. Like lovastatin, Simvastatin is a specific inhibitor of HMG-CoA reductase and is used in vivo to reduce LDL cholesterol. More recently, the statins have become important biochemical probes in cell biology. Their involvement in many events can be correlated to their primary mode of action, however, the mechanism of action of many other effects is less apparent.
Simvastatin is soluble in ethanol, methanol, DMF and DMSO.
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Lovastatin and simvastatin are modulators of the proteasome. Wojcik C. et al. Int. J. Biochem. Cell Biol. 2000, 32, 957.
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy. Danesh F. R. et al. Proc. Natl. Acad. Sci. USA 2002, 99, 8301.
HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Xu H. et al. Am. J. Physiol. Renal. Physiol. 2006, 291, F995.