SKU: S114  / 
    CAS Number: 131929-60-7

    Spinosyn A, >95%

    $162.23 - $333.10

    Spinosyn A, >95% is the major component of Spinosad, a complex of hydrophobic macrocyclic lactones isolated from the soil-dwelling bacterium, Saccharopolyspora spinosa.  Spinosyn A is a potent insecticide for crop pathogens and ectoparasite control in animals. Spinosyn A disrupts nicotinic acetylcholine receptors and resembles a GABA antagonist and affects insect neurons.

    Spinosyn A is soluble in ethanol, methanol, DMF and DMSO. 

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    Mechanism of ActionThe spinosyns have a unique mechanism of action involving disruption of nicotinic acetylcholinesterase receptors (nAChRs) which lead to disruption of acetylcholine neurotransmission which affects the insect nervous system.
    Plant Biology ApplicationsSpinosad is a natural product approved for use in organic agriculture as an insecticide and crop protectant. It has an excellent environmental and mammalian toxicological profile.
    ReferencesKirst HA (2010) The spinosyn family of insecticides: Realizing the potential of natural products research. J. Antibiotics 63:101-111 Kirst H.A. et al (191) A 83543A-D, unique fermentation-derived tetracyclic macrolides. Tetrahedron Lett. 32:4839 Lopez O and Fernandez-Bolanos JG ed. (2011) The Spinosyn insecticides. In: Green trends in insect control. RSC Green Chemistry Series No. 11, RSC Publishing, Ch. 5: pp 163-212