Spinosyn A, >95% is the major component of Spinosad, a complex of hydrophobic macrocyclic lactones isolated from the soil-dwelling bacterium, Saccharopolyspora spinosa. Spinosyn A is a potent insecticide for crop pathogens and ectoparasite control in animals. Spinosyn A disrupts nicotinic acetylcholine receptors and resembles a GABA antagonist and affects insect neurons.
Spinosyn A is soluble in ethanol, methanol, DMF and DMSO.
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| Mechanism of Action | The spinosyns have a unique mechanism of action involving disruption of nicotinic acetylcholinesterase receptors (nAChRs) which lead to disruption of acetylcholine neurotransmission which affects the insect nervous system. |
| Plant Biology Applications | Spinosad is a natural product approved for use in organic agriculture as an insecticide and crop protectant. It has an excellent environmental and mammalian toxicological profile. |
| References | Kirst HA (2010) The spinosyn family of insecticides: Realizing the potential of natural products research. J. Antibiotics 63:101-111 Kirst H.A. et al (191) A 83543A-D, unique fermentation-derived tetracyclic macrolides. Tetrahedron Lett. 32:4839 Lopez O and Fernandez-Bolanos JG ed. (2011) The Spinosyn insecticides. In: Green trends in insect control. RSC Green Chemistry Series No. 11, RSC Publishing, Ch. 5: pp 163-212 |
