Spiramycin is a broad-spectrum 16-membered ring macrolide antibiotic composed of a mixture of spiramycin I, II, and III. Spiramycin was first isolated by PINNERT-SINDICO in 1954 from Streptomyces ambofaciens.
Spiramycin is a bacterial protein synthesis inhibitor, it works by irreversibly binding to the P-site on the 50s ribosome, preventing peptide bond formation and translocation. Spiramycin is effective against gram-negative and gram-positive bacteria, as well as some Toxoplasma parasites.
Spiramycin has shown anti-obesity effects. In a recent study (2016), it was shown that spiramycin inhibits adipogenesis in 3T3-L1 cells and ameliorates obesity and associated metabolic indications in HFD-fed mice.
Synonyms: Rovamycine, Formacidine, Foromacidine, NSC 55926, Kitasamycin
We also offer:
- Spiramycin I (S094)
